The peer-reviewed, open access International Journal of Entomology Research offers speedy publishing of manuscripts in all fields of entomology research and associated fields. This journal's goal is to give scientists and researchers from all around the world a forum where they can exchange, promote, and discuss a wide range of cutting-edge concepts and advancements in all areas of entomology study. Manuscripts that satisfy the general requirements of relevance and scientific excellence are welcome submissions to the journal. After acceptance, papers will be published shortly. Peer review is applied to every manuscript published in International Journal of Entomology Research.

Malaria threatens an estimated 3.8 billion people, or half of the world's population, and has a serious influence on global public health. The emergence of drug-resistant malaria parasites in recent years has brought to light the urgent need to identify fresh targets for the creation of cutting-edge antimalarial drugs. Furthermore, very little is understood about the molecular mechanisms that underlie parasite life and disease. It is still not completely understood how parasite effector proteins are transported to important subcellular compartments like the host cell membrane. Lack of knowledge of these procedures hinders comprehension of the biology of the malaria parasite and affects attempts to control the infection.

Structure determination is important in addressing these unknowns because it frequently reveals previously hidden interactions and pathways, providing vital information about the functions and molecular mechanisms of potential therapeutic targets. Unfortunately, structural and biochemical studies of some crucial Plasmodium falciparum protein complexes using conventional techniques have been hampered by the difficulties in replicating the proper folding and assembly of malarial protein complexes in heterologous systems. It is challenging to clone into heterologous expression platforms, for instance, since the Plasmodium falciparum genome has a high AT content (average AT content of 80.6%) and a significantly skewed codon use bias. The majority of the proteome is prone to aggregation and is filled with low-complexity regions, despite the fact that codon optimization techniques have helped to lessen this issue. Large-scale charged-residue repeats are present in a number of Plasmodium falciparum proteins, which makes heterologous synthesis challenging.

Traditional techniques like x-ray crystallography and nuclear magnetic resonance (NMR), which heavily rely on the production of significant quantities of highly purified protein by recombinant overexpression, have been hampered by these obstacles in structural studies of the Plasmodium falciparum proteome. These barriers have made it difficult to learn more about the biology of novel malaria parasites. The molecular mechanisms underpinning the parasite's ability to hijack human erythrocytes are still poorly understood in many cases.

The single-cell, eukaryotic Plasmodium parasites that cause malaria are parasites. The Plasmodium species that infects people, Plasmodium falciparum, is linked to the most deadly and severe illness manifestations. The primary host of Plasmodium falciparum is the Anopheles mosquito, which transmits the parasites to humans during a blood meal. A newly infected person's parasites travel to the liver, where they quickly multiply before egressing into the bloodstream to start the asexual replication cycle that occurs within erythrocytes (red blood cells, RBCs). The fact that all clinical manifestations of malaria are accompanied by intra erythrocytic, asexual parasite replication highlights the importance of understanding the asexual lifecycle.